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UNIT 1. BIOLOGICAL CHEMISTRY

Lecture 2. Chemical Foundations for Cells/Biochemicals of Cells

1.  Objective

The first objective of this lecture  is to introduce students to the basics of principles of inorganic, organic, and biochemistry needed to understand structure and function of organisms and biological systems. It emphasizes the major groups of biochemicals and their involvement in the metabolism of organisms and its regulation.

2Chemical Foundations for Cells

2.1.  Elements 

bulletelemental compostion (2-1)

2.1.1.  Atoms and Bonds

2.1.1.1.  Atomic Structures (2-2)

2.1.1.2.   Isotopes (2-3)

2.1.1.3.  Ionic, Covalent, and Hydrogen Bonds
bulletionic bonding (2-4)
bulletcovalent bonding in hydrogen (2-5)
bullethydrogen bonding in water (2-6)

2.2.  Properties of Water

2.2.1.  Abundance

2.2.2.  Fluidity

2.2.3.  Polarity

2.2.4.  Physical States (2-7)

2.2.5.  Thermal and Evaporative Properties

bulletcalorie definition (2-8)
bullet

resistant to change in temperature

2.2.6. Density

water density vs temperature (2-9)

2.2.7.  Surface Tension (2-10)

2.2.8.  Transparency

2.3.  Anions and Cations

common anions and cations (2-11)

2.4. Acids, Bases, and Salts

2.4.1.  Acids and Bases

2.4.2.  PH and buffers

bulletpH scale (2-12)
bulletbicarbonate buffer system (2-13)
bulletdissolved salts (2-14)

3.  Biochemicals of Cells

3.1.  Properties of Carbon Compounds

bulletcovalent bonding in methane (2-15)
bullethydrocarbon skeletons (2-16)
bulletfunctional groups (2-17)

3.2.  Carbohydrates

bulletstructure of monosaccharides (2-18)
bulletglucose chain structure (2-19)
bulletglucose ring structure (2-20)
bulletmaltose, lactose, and sucrose (2-21)
bulletstarch (2-22)
bulletcellulose and chitin (2-23)

3.3.  Lipids

bulletfree fatty acids (2-24)
bulletsaturated and unsaturated fatty acids (2-25)
bulletfatty acid esters (2-26)
bulletsynthesis of a fat (2-27)
bulletphospholipid (2-28)

3.4.  Proteins

bulletpolypeptide structure (2-29)
bulletnonpolar amino acids (2-30)
bulletpolar amino acids (2-31)
bulletionic amino acids (2-32)
bulletessential amino acids
bulletprotein structures (2-33)
bullettertiary structure of myoglobin (2-34)
bulletquaternary structure of hemoglobin (2-35)

3.5.  Nucleotides and Nucleic Acids

bulletpurines and pyrimidines (2-36)
bulletstructure of nucleotides (2-37)
bulletNADH (2-38)
bulletnucleic acids and hydrogen bonds (2-39)
bulletbases in double stranded DNA (2-40)
bulletcoiled double stranded DNA (2-41)
bulletRNA resembles DNA except:
bulletIt has uracil instead of thymine
bulletIt has ribose instead of deoxyribose
bulletIt is single stranded (DNA is usually but not always double stranded)

3.6.  Others (vitamins, hormones, cofactors)

bulletvitamin beta carotene (2-42)
bulletsterols, e.g., typical hormones (2-43)
bulletcofactor chlorophyll a (2-44)
bulletlignin model (2-45)

4.  Critical Concepts or Questions

4.1.  What are three major differences in the elemental composition of plants and animals?

4.2.  Rank the strength of hydrogen, covalent, and ionic bonds (higher to lower) and give one example of each (draw structures).

4.3.  How does ionic bonding influence the properties of water?  What would be an ecological problem if water had its highest density at the freezing point?

4.4.  Memorize the common cations and anions.

4.5.  What is an acid, base, salt, and buffer?  What is the main buffer in humans?

4.6.  Give examples of natural environments that have low, neutral, and high pH.

4.7.  You should be able to draw the major functional groups used in biochemicals.

4.8.  You should be able to recognize each of the types of biochemicals presented and one or more examples of their function.

4.9.  Specifically you should be able to draw the structures of glucose, sucrose, ribose, deoxyribose, adenine, quanine, cytosine, thymine, uracil, ATP, and NAD.

4.10.  You should know which purines and pyrimidines are attracted in DNA replication.

4.11.  What is meant by primary, secondary, tertiary, and quatenary structure of proteins?

5.  Vocabulary

acid enzyme nucleic acid
amino acid fatty acid nucleotide
atom functional group pH scale
atomic number hydrogen bond phospholipid
base hydrogen ion (H+) polypeptide chain
buffer hydrolysis protein
carbohydrate ion proton
condensation ionic bond radioisotope
covalent bond lipid salt
denaturation mass number molecule
electron    

6.  Webpage Links

Frank Potter's Science Gems - Physical Scienc...

Theory of Atoms in Molecules: Introduction

Enzyme Biochemistry Chapter

Abbreviations of Chemical Compounds

Eric's Treasure Trove of Chemistry

GlossaryTrove of Chemistry

Movies Trove of Chemistry  Multimedia Movies including: Docking (transition from Trypsinogen into Trypsin); DLPE Bilayer; Argon Cluster; 3D Texture Mapping; Vibrations; Cellulose Morphing; Wave Packet; Proton Transfer, etc. Make your own molecular movies!! 

ChemFinder Searching  "At the moment, this database contains an eclectic 2500 compounds. We are particularly well represented in small biological molecules, including sugars, amino acids, nucleic acids, and steroids. We also have large selections of drugs and dyes, with particular emphasis on household items."

General Organic and Biochemistry - Physical Scie Some animations. Lecture slide series: Chemical reactions; solutions; acids/bases; reaction rates; alkanes; phenols; amines; enzymes; nucleic acids; carbohydrate metabolism; etc. Copyrighted.

Amino Acid Basics   Animated (gif images) introduction to what defines an amino acid.

7. Illustration Documentation