Lecture 14

Microbial Transmission of Diseases

1.  Objective

The objective is to introduce the types diseases of humans and plants caused by organisms and factors influencing their occurrence, distribution and control.

2.  Epidemiology

2.1.  Definitions

bulletepidemiology

- study of occurrence, distribution, and control of diseases in populations

- origin, spread or communication, and eradication of disease

bulletincidence - number of diseased individuals in a defined population
bulletendemic - constantly present disease
bulletepidemic - abnormally high incidence locally
bulletpandemic - abnormally high incidence over a wide geographic area
bulletoutbreak - short-term local increase in a disease
bulletmorbidity - all cases, fatal and nonfatal
bulletmortality - fatal cases
bulletherd immunity - if the proportion of immune individuals is sufficiently high, then the whole population is protected

2.2.  Patterns of Disease in Developed Versus Underdeveloped Countries

bulletCauses of death worldwide
bulletCauses of death in developed and underdeveloped countries (14-2)
bulletRecent worldwide outbreaks (14-4)

2.3.  Control of Epidemics

2.3.1.  Improved resistance
bulletnutrition
bulletreduce people concentration
bulletlighter work loads

2.3.2.  Control Reservoir
bulletmosquitoes
bulletimmunize animals (e.g. rabies)

2.3.3.  Control transmission
bulletdirect contact
bulletfood
bulletwater
bulletair
bulletfeces

2.3.4.  Examples
bulletmeasles (14-5)
bulletrubella (14-6)
bulletmumps (14-7) (photo) (14-8)

2.3.4.  Immunizations Recommended for Foreign Travel

cholera, yellow fever, plague, infectious hepatitis A, serum hepatitis B, typhoid fever, malaria

 

3.  Direct Contact

3.1.  Sexually Transmitted Diseases (14-9)

3.1.1.  time profile of STD (14-10)

3.1.2.  time profile of gonorrhea (14-11)

bulleteasily treated
bulletno acquired immunity
bulletuse of oral contraceptives favors disease
bulletsymptoms are mild

3.2.  AIDS (Acquired Immunodeficiency Syndrome)

3.2.1.  time profile of AIDS (14-12)

3.2.2.  Incidence of AIDS if different countries

3.2.3.  causes of AIDS in men (14-13)

3.2.4.  causes of AIDS in women (14-14)

3.2.5.  process of HIV infection (A) (14-15) (B) (14-16)

3.2.6.  lymphocyte releasing HIV virus (14-17)

3.2.7.  course of development of AIDS (14-18)

bulletOpportunistic pathogens and malignancies cause death.

3.2.8.  treatment of AIDS
bulletAZT (14-19) (azidothymidine; reverse transcriptase inhibitor; inhibits the enzyme that converts single-stranded RNA into complementary DNA; stops virus replication)
bulletnon-reverse transcriptase inhibitors (interferes with protein- altering catalytic site)
bulletprotease inhibitors (inhibits processing of viral polypeptide and viral maturation)
bulletfusion inhibitors inhibit binding of virus to target cells (DC4)

3.3.  Diseases Transmitted by Animal Vectors

3.3.1.  rabies (14-20)

3.3.2.  Lyme disease (A) (14-21) (B) (14-22)
bulletcaused by Borrelia burgdorferi
bulletdeer tick is vector

3.3.3.  plague (A) (14-23) (B) (14-24)
bulletcaused by Yersinia pestis
bulletfleas and rats are vectors

3.3.4.  malaria (A) (14-25) (B) (14-26)
bulletcaused by Plasmodium vivax (protozoan)
bulletmosquitoes are vectors

3.4.  Other

3.4.1.  staphylococcal infections
bulletboils (14-27) and pimples (14-28)
bullettoxic shock syndrome

3.4.2.  tetanus (Clostridium tetani)

3.4.3.  fungus

3.4.4.  tooth decay (14-29) (Streptococcus)

 

4.  Airborne (14-30)

4.1.  Pathogens and Their Site of Infection (14-31)

bulletincidence of influenza and cold (14-32)
bulletmap of flu outbreaks (14-33)
bullettuberculosis (Mycobacterium tuberculosis)

4.2.  Allergies Caused by Microorganisms

bulletcategories of indoor air pollutants (14-34)
bulletmicroorganisms causing indoor air problems (14-35)
bulletindoor air quality related illnesses (14-36)
bulletincidence of legionellosis (14-37)

4.3.  Control (Ozone Seminar)

 

4.3.1.  abatement of indoor air pollutants (14-38)

bulletair filters (14-39)

5.  Foodborne

5.1.  List of Diseases

5.2.  Food Poisoning

bulletStaphylococcus
bulletClostridium perfringens
bulletbotulism (14-41)
bulletaflatoxins (14-42)

5.3.  Food Infection

bulletCampylobacteriosis - most prevalent food related infection; bloody stool, cramps; present in all fowl carcasses; also associated with shellfish, pork and domestic animals
bulletsalmonellosis (14-43)
bullethepatitis (14-44)
bulletMad cow disease (variant Creutzfeldt-Jakob disease; caused by prion (heat stable proteins that replicate themselves and attack the nervous system

5.4.  Control

 

6.  Waterborne

6.1.  Table of Waterborne Diseases

6.2.  Recreational Waterborne Diseases

6.3.  Protozoa

bulletGiardia
bulletCryptosporidium

6.4.  Recent Outbreaks

bulletCryptosporidium - 400,000 cases in Milwaukee in 1993; probably related to contamination of drinking water by cattle; highly resistant to chlorination
bulletEscherichia coli O157:H7 - a new highly pathogenic strain
bulletPfiesteria - a dinoflagellate caused by nutrient discharge in waters; causes memory loss and other symptoms

6.5.  Control

bulleteffect of water and waste treatment (14-46)
bulletindicator organisms (14-47)

 

7.  Nosocomial Diseases (14-48)

 

 

9.  Critical Concepts or Questions

9.1.  Compare the major diseases and causes in developed and underdeveloped countries.

9.2.  What are methods of controlling transmission and resistance to diseases?

9.3.  What has been the primary method of controlling airborne viral and intestinal diseases in the U.S?

9.4.  What are two sexually transmitted diseases for which their is no know cure?   Why is development of a cure difficult?

9.5.  What is the cause of AIDs?  How is it transmitted?  How does it cause death?  What are some preventative measures?

9.6.  Why do we have no major incidence of malaria and plague in the U.S.?

9.7.  What is the difference in food poison and food infection?  Give examples of each?  How can you avoid each?

9.8.  Outline the causes, consequences, and control measures of indoor air contaminated with microbes?

9.9.  How would you avoid getting a waterborne disease when visiting an underdeveloped country?

9.10.  How would you avoid getting a foodborne disease when visiting an underdeveloped country?

9.11.  Why does the U.S. have limited incidence of waterborne and foodborne diseases?

9.12.  How would you avoid nosocomial infections when in hospitals?

 

10.  Vocabulary

epidemiology incidence epidemic
mortality morbidity AIDS
food poisoning food infection vector
immunity nosocomial vaccination
immunization endemic epidemic
pathogen virulence streptococcal
legionaire's disease herpes lyme disease
malaria traveler's diarrhea chlorination

11.  Webpage Links

Texas Plant Disease Handbook You may locate the information you want by selecting a host from the Host Index. The old format, which doesn't require support for forms, is available, but may not contain the latest revisions.

UF Plant Path 
http://plantpath.ifas.ufl.edu/
I am pleased and honored to have the opportunity to present to you this web page which describes the people, the places and some facts relevant to the graduate and undergraduate programs in plant pathology at the University of Florida.

Online Guide to Plant Disease Control  
http://www.agnic.org/agdb/ogpdc.html
Brief Description: A master index to plant diseases is arranged alphabetically, first by the common name of the crop, and then by the common name of the disease.

Rabies 
http://www.austinspca.com/rabies.html
Rabies is a disease that affects the central nervous system and usually results in death. Most rabies cases occur in skunks, bats, racoons, coyotes, dogs, cats, and farm animals.

APHIS Web -- Animal Health  
http://www.aphis.usda.gov/oa/new/ah.html
USDA Animal and Plant Health Inspection Service Protecting the health of American animal agriculture is an important goal of USDA's Animal and Plant Health Inspection Service (APHIS).

 

12.  Illustration Documentation